Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil produced similar .. such as barbiturates, will decrease plasma levels of vardenafil. supratherapeutic (80 mg) doses of vardenafil produced increases in QTc interval. . Twenty-four hours after co-administration, the plasma levels of vardenafil. Vardenafil therapy was statistically (p level of Gemifloxacin may also prolong the Therapeytic interval in some patients, with the maximal change in the QTc interval occurring approximately 5 to 10 hours following oral administration. Substantially increased vardenafil plasma concentrations may result in increased associated adverse events therapeugic hypotension, syncope, visual changes, and prolonged erection. If concomitant use is unavoidable, closely monitor ECGs for QT prolongation and monitor electrolytes; correct hypokalemia or hypomagnesemia https://vardenafilfast.com/wiki-levitra.html to administration of toremifene. Amoxicillin; Clarithromycin; Omeprazole: Major The manufacturer of clarithromycin a CYP3A4 inhibitor recommends against concomitant use with vardenafil a CYP3A4 substrate ; as use of these drugs together will result in increased vardenafil exposure. Prepak Systems Inc. See full drug interaction monograph for details. Vardenafil may decrease the excretion rate of Metildigoxin which could result in a higher serum level. Related Drug Information Drug Summary. The risk or severity of QTc prolongation can be increased when Vardenafil is combined with Difloxacin. Send the page " " to a friend, relative, colleague or visit web page. The vardenafil orally disintegrating tablets ODTs provide increased exposure as compared to the regular tablets; therefore, use of the vardenafil ODTs with potent CYP3A4 inhibitors should be avoided. If these drugs must be administered together, a lower dose of vardenafil is required. Coadministration may increase the risk for QT prolongation.