How Long Does Sildenafil Take to Start Working? Other common ED drugs include Cialis and Levitra, both of which have similar positive. As with many other types of medication, erectile dysfunction drugs like Levitra do not work equally well for everyone. Some men may find a 10mg highly effective. It reduces the action of the natural chemical in your body which makes erections go away. Levitra allows an erection to last long enough for you to satisfactorily.